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Article

Derivation of Breast Cancer Cell Lines Under Physiological (5%) Oxygen Concentrations

12 Oct 2018

Abstract excerpt

Background: Most human breast cancer cell lines currently in use were developed and cultured under ambient (20%) oxygen conditions. This is convenient in practical terms, but higher ambient oxygen increases the production of oxygen radicals, potentially modulating numerous signaling pathways and favoring the emergence of oxygen radical-resistant cell lines. We have derived a series of human cancer cell lines...

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Identifiers

PMID: 30370249
DOI: 10.3389/fonc.2018.00425

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