Article
Part III. Molecular changes induced by high nitric oxide adaptation in human breast cancer cell line BT-20 (BT-20-HNO): a switch from aerobic to anaerobic metabolism.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Feb 2013
De Vitto H, Mendonça B S, Elseth K M, Onul A, Xue J, Vesper B J, Gallo C V M, Rumjanek F D, Paradise W A, Radosevich J A
Abstract excerpt
Nutrient deprivation and reactive oxygen species (ROS) play an important role in breast cancer mitochondrial adaptation. Adaptations to these conditions allow cells to survive in the stressful microenvironment of the tumor bed. This study is directed at defining the consequences of High Nitric Oxide (HNO) exposure to mitochondria in human breast cancer cells. The breast cancer cell line BT-20 (parent) was adapted...
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