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Advances in understanding the mechanisms of the human papillomavirus oncoproteins

16 May 2025

Abstract excerpt

High-risk human papillomaviruses (HPVs) are responsible for almost all cervical cancer cases and a growing number of oropharyngeal and anogenital cancers. The primary HPV oncoproteins, E6 and E7, act together to manipulate multiple cellular pathways that can ultimately result in malignant transformation. This includes the deregulation of several signalling pathways that regulate cell proliferation, cell cycle...

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PMID: 40380881
DOI: 10.1042/bst20253041

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