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Article

Postzygotic mosaicism in cerebral cavernous malformation

24 Aug 2019

Abstract excerpt

Background Cerebral cavernous malformations (CCMs) can cause severe neurological morbidity but our understanding of the mechanisms that drive CCM formation and growth is still incomplete. Recent experimental data suggest that dysfunctional CCM3-deficient endothelial cell clones form cavernous lesions in conjunction with normal endothelial cells. Objective In this study, we addressed the question whether...

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PMID: 31446422
DOI: 10.1136/jmedgenet-2019-106182

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