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Genome-wide differential methylation analyses identifies methylation signatures of male infertility

17 Oct 2018

Abstract excerpt

STUDY QUESTION: Do methylation changes in sperm DNA correlate with infertility? STUDY ANSWER: Loss of spermatogenesis and fertility was correlated with 1680 differentially-methylated CpGs (DMCs) across 1052 genes. WHAT IS KNOWN ALREADY: Methylation changes in a number of genes have been correlated with reduced sperm count and motility. STUDY DESIGN, SIZE, DURATION: This case-control study used spermatozoal DNA...

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PMID: 30358834
DOI: 10.1093/humrep/dey319

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