Article
Analyses of inter-individual variations of sperm DNA methylation and their potential implications in cattle.
BMC genomics - 21 Nov 2019
Liu Shuli, Fang Lingzhao, Zhou Yang, Santos Daniel J A, Xiang Ruidong, Daetwyler Hans D, Chamberlain Amanda J, Cole John B, Li Cong-Jun, Yu Ying, Ma Li, Zhang Shengli, Liu George E
Abstract excerpt
BACKGROUND: DNA methylation has been shown to be involved in many biological processes, including X chromosome inactivation in females, paternal genomic imprinting, and others. RESULTS: Based on the correlation patterns of methylation levels of neighboring CpG sites among 28 sperm whole genome bisulfite sequencing (WGBS) data (486 × coverage), we obtained 31,272 methylation haplotype blocks (MHBs). Among them, we...
Topics
- Animals
- Biological Variation, Population
- Cattle
- DNA Methylation
- Genetic Variation
- Haplotypes
- Male
- Quantitative Trait Loci
- Reproduction
- Spermatozoa