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Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility

9 Mar 2015

Abstract excerpt

STUDY QUESTION: Are there DNA methylation alterations in sperm that could explain the reduced biological fertility of male partners from couples with unexplained infertility? SUMMARY ANSWER: DNA methylation patterns, not only at specific loci but also at Alu Yb8 repetitive sequences, are altered in infertile individuals compared with fertile controls. WHAT IS KNOWN ALREADY: Aberrant DNA methylation of sperm has...

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PMID: 25753583
DOI: 10.1093/humrep/dev053

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