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Broad <scp>DNA</scp> methylation changes of spermatogenesis, inflammation and immune response‐related genes in a subgroup of sperm samples for assisted reproduction

28 Aug 2013

Abstract excerpt

Aberrant sperm DNA methylation patterns, mainly in imprinted genes, have been associated with male subfertility and oligospermia. Here, we performed a genome-wide methylation analysis in sperm samples representing a wide range of semen parameters. Sperm DNA samples of 38 males attending a fertility centre were analysed with Illumina HumanMethylation27 BeadChips, which quantify methylation of >27 000 CpG sites in...

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PMID: 23996961
DOI: 10.1111/j.2047-2927.2013.00122.x

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