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Integrated Analysis of DNA Methylation and mRNA Expression Profiles to Identify Key Genes in Severe Oligozoospermia

12 May 2017

Abstract excerpt

Severe oligozoospermia (SO) is a complex disorder, whose etiology is the combined effect of genetic factors and epigenetic conditions. In this study, we examined DNA methylation and mRNA expression status in a set of testicular tissues of SO patients (n=3), and compared methylated data with those derived from obstructive azoospermia (OA) patients (n=3) with normal spermatogenesis phenotype. We identified 1960...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Identifiers

PMID: 28553232
DOI: 10.3389/fphys.2017.00261

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