Clinicopathological and Molecular Profiling of Adult-Type Diffuse Glioma Using Immunohistochemistry and Real-Time Polymerase Chain Reaction: Study from a Tertiary Care Cancer Center in Western India.

Abstract excerpt

BACKGROUND: Current advances in the classification of diffuse gliomas advocate integrated diagnosis combining histological and molecular parameters. However, in view of economical constraints for molecular testing, surrogate IHC molecular markers for IDH1 R132H, ATRX, and p53 can be used. OBJECTIVE: To classify AT-DG as per WHO 2021 using IHC surrogate molecular markers for IDH1 R132H, ATRX, and p53 in an...

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