Article
Rapid Intraoperative Molecular Characterization of Glioma.
JAMA oncology - 1 Aug 2015
Shankar Ganesh M, Francis Joshua M, Rinne Mikael L, Ramkissoon Shakti H, Huang Franklin W, Venteicher Andrew S, Akama-Garren Elliot H, Kang Yun Jee, Lelic Nina, Kim James C, Brown Loreal E, Charbonneau Sarah K, Golby Alexandra J, Sekhar Pedamallu Chandra, Hoang Mai P, Sullivan Ryan J, Cherniack Andrew D, Garraway Levi A, Stemmer-Rachamimov Anat, Reardon David A, Wen Patrick Y, Brastianos Priscilla K, Curry William T, Barker Fred G, Hahn William C, Nahed Brian V, Ligon Keith L, Louis David N, Cahill Daniel P, Meyerson Matthew
Abstract excerpt
IMPORTANCE: Conclusive intraoperative pathologic confirmation of diffuse infiltrative glioma guides the decision to pursue definitive neurosurgical resection. Establishing the intraoperative diagnosis by histologic analysis can be difficult in low-cellularity infiltrative gliomas. Therefore, we developed a rapid and sensitive genotyping assay to detect somatic single-nucleotide variants in the telomerase reverse...
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