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Culture of human alveolar epithelial type II cells by sprouting

19 Oct 2018

Abstract excerpt

BACKGROUND: Type II alveolar epithelial cells (AT2) play a pivotal role in maintaining the integrity and function of the alveoli. Only recently, the role of impaired epithelial repair mechanisms after injury in the pathogenesis of idiopathic pulmonary fibrosis has been demonstrated, and has shifted the AT2 cell in the focus of interest. Therefore, using primary human AT2 cells instead of cell lines for in vitro...

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PMID: 30340591
DOI: 10.1186/s12931-018-0906-9

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