Article
Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.
American journal of respiratory cell and molecular biology - 1 Aug 2018
Sucre Jennifer M S, Jetter Christopher S, Loomans Holli, Williams Janice, Plosa Erin J, Benjamin John T, Young Lisa R, Kropski Jonathan A, Calvi Carla L, Kook Seunghyi, Wang Ping, Gleaves Linda, Eskaros Adel, Goetzl Laura, Blackwell Timothy S, Guttentag Susan H, Zijlstra Andries
Abstract excerpt
Alveolar type II (AT2) epithelial cells are uniquely specialized to produce surfactant in the lung and act as progenitor cells in the process of repair after lung injury. AT2 cell injury has been implicated in several lung diseases, including idiopathic pulmonary fibrosis and bronchopulmonary dysplasia. The inability to maintain primary AT2 cells in culture has been a significant barrier in the investigation of...
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