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Article

Differentiation of Club Cells to Alveolar Epithelial Cells In Vitro.

Scientific reports - 27 Jan 2017

Zheng Dahai, Soh Boon-Seng, Yin Lu, Hu Guangan, Chen Qingfeng, Choi Hyungwon, Han Jongyoon, Chow Vincent T K, Chen Jianzhu

Abstract excerpt

Club cells are known to function as regional progenitor cells to repair the bronchiolar epithelium in response to lung damage. By lineage tracing in mice, we have shown recently that club cells also give rise to alveolar type 2 cells (AT2s) and alveolar type 1 cells (AT1s) during the repair of the damaged alveolar epithelium. Here, we show that when highly purified, anatomically and phenotypically confirmed club...

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Identifiers

PMID: 28128362
DOI: 10.1038/srep41661
PMCID: PMC5269679

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