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Article

IgG4 drives M2a macrophages to a regulatory M2b‐like phenotype: potential implication in immune tolerance

19 Oct 2018

Abstract excerpt

BACKGROUND: Macrophages can be converted in vitro into immunoregulatory M2b macrophages in the presence of immune complexes (ICs), but the role of the specific subclasses IgG1 or IgG4 in this phenotypic and functional change is not known. OBJECTIVE: We aimed to refine the original method by applying precisely defined ICs of the subclasses IgG4 or IgG1 constructed by two independent methods. METHODS:...

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PMID: 30338531
DOI: 10.1111/all.13635

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