Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fc gamma receptor IIb on GM-CSF macrophages controls immune complex mediated inhibition of inflammatory signals.

PloS one - 1 Jan 2014

Santegoets Kim C M, Wenink Mark H, van den Berg Wim B, Radstake Timothy R D J

Abstract excerpt

BACKGROUND: In rheumatoid arthritis (RA) macrophages play a major role in amplifying synovial inflammation. Important activating signals are those induced by Toll-like receptor (TLR) ligands and by activated T cells. The balance between activating and inhibitory Fc gamma receptors (FcγRs) on macrophages might be crucial in modulating these inflammatory responses. The purpose of this study was to determine FcγR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen-Antibody Complex
Share to Coculture Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Granulocyte-Macrophage Colony-Stimulating Factor

Share to Interleukin-10

Share to Monocytes

Share to Phagocytosis

Share to Phosphatidylinositol 3-Kinases

Share to Receptors, IgG

Source

Open in PubMed Open full text

Identifiers

PMID: 25340460
DOI: 10.1371/journal.pone.0110966
PMCID: PMC4207781

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fc gamma receptor IIb on GM-CSF macrophages controls immune complex mediated inhibition of inflammatory signals.PMID 25340460Read ↗

A shift in the balance of inhibitory and activating Fcgamma receptors on monocytes toward the inhibitory Fcgamma receptor IIb is associated with prevention of monocyte activation in rheumatoid arthritis.Semantic proximity Read ↗

Understanding Fc Receptor Involvement in Inflammatory Diseases: From Mechanisms to New Therapeutic ToolsSemantic proximity Read ↗

A Comprehensive Review of Fc Gamma Receptors and Their Role in SLESemantic proximity Read ↗

Fc-dependent mechanisms of action: roles of FcγR and FcRn.Semantic proximity Read ↗

IgG Fc ReceptorsSemantic proximity Read ↗

Human receptors for immunoglobulin G: Key elements in the pathogenesis of rheumatic diseaseSemantic proximity Read ↗

FcγRIIa cross-talk with TLRs, IL-1R, and IFNγR selectively modulates cytokine production in human myeloid cells.Semantic proximity Read ↗

FcγRIIB as a modulator of autoimmune disease susceptibilitySemantic proximity Read ↗

Identification and structural characterization of Fc gamma-receptors on pulmonary alveolar macrophages.Semantic proximity Read ↗

The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis.Semantic proximity Read ↗

Fc Receptors and Their Role in Immune Regulation and AutoimmunitySemantic proximity Read ↗

TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1/M2 phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.