Article
Characterization of macrophage phenotypes in three murine models of house-dust-mite-induced asthma.
Mediators of inflammation - 1 Jan 2013
Draijer Christina, Robbe Patricia, Boorsma Carian E, Hylkema Machteld N, Melgert Barbro N
Abstract excerpt
In asthma, an important role for innate immunity is increasingly being recognized. Key innate immune cells in the lungs are macrophages. Depending on the signals they receive, macrophages can at least have an M1, M2, or M2-like phenotype. It is unknown how these macrophage phenotypes behave with regard to (the severity of) asthma. We have quantified the phenotypes in three models of house dust mite (HDM-)induced...
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