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Article

Macrophage phenotype modulation via 2-hydroxypropyltrimethyl ammonium chloride chitosan: a novel strategy for managing allergic rhinitis.

Biomaterials science - 5 May 2026

Peng Yi, Meng Cuida, Liu Yu, Li Kejia, Zhu Meng, Ju Xiaoyan, Tian Ye, Zhu Dongdong, Niu Zhongwei

Abstract excerpt

Allergic rhinitis (AR) is a chronic nasal disease primarily mediated by immunoglobulin E (IgE). This condition significantly impairs patients' quality of life. Current treatments have limited clinical effectiveness. Although TH2 lymphocytes are well established as key regulators in AR pathogenesis, recent evidence underscores the pivotal role of M2 macrophages, particularly the M2a subtype, in exacerbating type 2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41945333
DOI: 10.1039/d6bm00169f

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AR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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