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Mycobacterium tuberculosis –induced IFN-β production requires cytosolic DNA and RNA sensing pathways

18 Oct 2018

Abstract excerpt

RNA sensing pathways are key elements in a host immune response to viral pathogens, but little is known of their importance during bacterial infections. We found that Mycobacterium tuberculosis (M.tb) actively releases RNA into the macrophage cytosol using the mycobacterial SecA2 and ESX-1 secretion systems. The cytosolic M.tb RNA induces IFN-β production through the host RIG-I/MAVS/IRF7 RNA sensing pathway. The...

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PMID: 30337468
DOI: 10.1084/jem.20180508

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