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Targeted RNA-Seq Reveals the M. tuberculosis Transcriptome from an In Vivo Infection Model

31 Aug 2021

Abstract excerpt

The study of host-pathogen interactions using in vivo models with intracellular pathogens like Mycobacterium tuberculosis (Mtb) entails technical limitations, such as: (i) Selecting an efficient differential lysis system to enrich the pathogen cells; (ii) obtaining sufficient high-quality RNA; and (iii) achieving an efficient rRNA depletion. Thus, some authors had used flow cytometers to separate infected cells...

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PMID: 34571725
DOI: 10.3390/biology10090848

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