Article
STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients.
Blood - 3 Oct 2013
Jerez Andres, Clemente Michael J, Makishima Hideki, Rajala Hanna, Gómez-Seguí Ines, Olson Thomas, McGraw Kathy, Przychodzen Bartlomiej, Kulasekararaj Austin, Afable Manuel, Husseinzadeh Holleh D, Hosono Naoko, LeBlanc Francis, Lagström Sonja, Zhang Dan, Ellonen Pekka, Tichelli André, Nissen Catherine, Lichtin Alan E, Wodnar-Filipowicz Aleksandra, Mufti Ghulam J, List Alan F, Mustjoki Satu, Loughran Thomas P, Maciejewski Jaroslaw P
Abstract excerpt
Large granular lymphocyte leukemia (LGL) is often associated with immune cytopenias and can cooccur in the context of aplastic anemia (AA) and myelodysplastic syndromes (MDS). We took advantage of the recent description of signal transducer and activator of transcription 3 (STAT3) mutations in LGL clonal expansions to test, using sensitive methods, for the presence of these mutations in a large cohort of 367 MDS...
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