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Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53

8 Jun 2021

Abstract excerpt

Despite a high clinical need for the treatment of colorectal carcinoma (CRC) as the second leading cause of cancer-related deaths, targeted therapies are still limited. The multifunctional enzyme Transglutaminase 2 (TGM2), which harbors transamidation and GTPase activity, has been implicated in the development and progression of different types of human cancers. However, the mechanism and role of TGM2 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34103685
DOI: 10.1038/s41388-021-01847-w

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