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Effects of tumor necrosis factor-α polymorphism on the brain structural changes of the patients with major depressive disorder

11 Oct 2018

Abstract excerpt

Single Nucleotide Polymorphic (SNP) variations of proinflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α) have been reported to be closely associated with the major depressive disorder (MDD). However, it is unclear if proinflammatory genetic burden adversely affects the regional gray matter volume in patients with MDD. The aim of this study was to test whether rs1799724, an SNP of TNF-α, contributes to...

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PMID: 30310056
DOI: 10.1038/s41398-018-0256-x

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