What we can learn from a tadpole about ciliopathies and airway diseases: Using systems biology in <i>Xenopus</i> to study cilia and mucociliary epithelia

Abstract excerpt

Over the past years, the Xenopus embryo has emerged as an incredibly useful model organism for studying the formation and function of cilia and ciliated epithelia in vivo. This has led to a variety of findings elucidating the molecular mechanisms of ciliated cell specification, basal body biogenesis, cilia assembly, and ciliary motility. These findings also revealed the deep functional conservation of signaling,...

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