Article

Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through transcriptional and epigenetic mechanisms

2024-10-27

Abstract excerpt

Foxi1 is a master regulator of ionocytes (ISCs / INCs) across species and organs. Two subtypes of ISCs exist, and both α-and β-ISCs regulate pH-and ion-homeostasis in epithelia. Gain and loss of FOXI1 function are associated with human diseases, including Pendred syndrome, male infertility, renal acidosis and cancers. Foxi1 was predominantly studied in the context of ISC specification, however, reports indicate ad...

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Literature Corpus work: 4af33626-a075-5485-bb8f-628038974112
DOI: 10.1101/2024.10.27.620464

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