Article

Epilepsy-associated potassium channel KCNT1 is required for multiciliated cell development in Xenopus

2026-04-03

Abstract excerpt

Pathogenic variants in the gene KCNT1 , which encodes a sodium-activated potassium channel, cause a severe neurodevelopmental disorder with intractable epilepsy. In addition to seizures, affected individuals commonly present with severe respiratory issues and structural heart defects not commonly observed in other genetic pediatric epilepsies, suggesting additional developmental functions for KCNT1 in organs beyo...

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Literature Corpus work: 4b2fefc0-66bb-5a10-94d2-0f766172a17a
DOI: 10.64898/2026.03.31.710877

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