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Article

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

2 Oct 2018

Abstract excerpt

A deeper epigenomic understanding of spatial organization of cells in human tissues is an important challenge. Here we report the first combined positional analysis of transcriptomes and methylomes across three micro-dissected zones (pericentral, intermediate and periportal) of human liver. We identify pronounced anti-correlated transcriptional and methylation gradients including a core of 271 genes controlling...

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PMID: 30297808
DOI: 10.1038/s41467-018-06611-5

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