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Article

CDK8 Maintains Tumor Dedifferentiation and Embryonic Stem Cell Pluripotency

17 Feb 2012

Abstract excerpt

CDK8 is a cyclin-dependent kinase that mediates transcriptional control of pathways linked to both cancer and stem cells. In this study, we show that CDK8 is required for both tumor growth and maintenance of tumor dedifferentiation in vivo and uncover a common role for CDK8 in controlling cancer and stem cell function. Acute CDK8 loss in vivo strongly inhibited tumor growth and promoted differentiation....

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PMID: 22345154
DOI: 10.1158/0008-5472.can-11-3886

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