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Article

Characterization of SOX2, OCT4 and NANOG in Ovarian Cancer Tumor-Initiating Cells

12 Jan 2021

Abstract excerpt

The identification of tumor-initiating cells (TICs) has traditionally relied on surface markers including CD133, CD44, CD117, and the aldehyde dehydrogenase (ALDH) enzyme, which have diverse expression across samples. A more reliable indication of TICs may include the expression of embryonic transcription factors that support long-term self-renewal, multipotency, and quiescence. We hypothesize that SOX2, OCT4,...

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PMID: 33445692
DOI: 10.3390/cancers13020262

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