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Article

Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches

8 Oct 2018

Abstract excerpt

Significance Osteoclasts play an essential role in bone homeostasis. Understanding how osteoclast differentiation is regulated is important in the context of pathological bone conditions and the hematopoietic stem cell (HSC) niche. We show that PTIP directly promotes chromatin changes required for Pparγ expression, a transcription factor essential for osteoclastogenesis. Deletion of PTIP disrupts the integrity of...

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PMID: 30297393
DOI: 10.1073/pnas.1806019115

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