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Article

ASXL1 impairs osteoclast formation by epigenetic regulation of NFATc1

28 Sept 2018

Abstract excerpt

Abstract Additional sex comb-like 1 (ASXL1) mutations are commonly associated with myeloid malignancies and are markers of aggressive disease. The fact that ASXL1 is necessary for myeloid differentiation raises the possibility it also regulates osteoclasts. We find deletion of ASXL1 in myeloid cells results in bone loss with increased abundance of osteoclasts. Because ASXL1 is an enhancer of trithorax and...

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Identifiers

PMID: 30266822
DOI: 10.1182/bloodadvances.2018018309

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