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Article

Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation

1 Nov 2023

Abstract excerpt

During osteoclast differentiation, the expression of the transcription factor nuclear factor of activated T cell 1 (Nfatc1) increases in an autoproliferative manner. Nfatc1 isoforms are of three sizes, and only the short isoform increases during osteoclast differentiation. Genetic ablation of the whole Nfatc1 gene demonstrated that it is essential for osteoclastogenesis; however, the specific role of the Nfatc1...

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PMID: 37914750
DOI: 10.1038/s41598-023-45909-3

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