Cannabidiol-induced Heme oxygenase-1 contributes to modulate the phenotype of hiPSC-derived cardiac fibroblasts from patients with Duchenne muscular dystrophy.

doi:10.1016/j.redox.2026.104333

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Article

Cannabidiol-induced Heme oxygenase-1 contributes to modulate the phenotype of hiPSC-derived cardiac fibroblasts from patients with Duchenne muscular dystrophy.

Redox biology - 1 Oct 2026

Savchenko L, Soussi S, Rovina D, Swiader A, Mallia S, Pompilio G, Kunduzova O, Parini A, Gowran A, Pizzinat N

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a severe and progressive form of muscular dystrophy caused by mutations in the dystrophin gene. We previously observed that loss of dystrophin in human induced pluripotent stem cell-derived cardiac fibroblasts (hiPSC-cFib) dysregulated the actin network and induced a metabolic remodeling associated with an exacerbated myofibroblast phenotype. The endocannabinoid signaling...

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Topics

Humans
Muscular Dystrophy, Duchenne
Cannabidiol
Heme Oxygenase-1
Induced Pluripotent Stem Cells
Fibroblasts

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Reactive Oxygen Species

Phenotype

Cell Differentiation

Cell Proliferation

Myocardium

Actins

Transforming Growth Factor beta

Myofibroblasts

Source

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Identifiers

PMID: 42579928
DOI: 10.1016/j.redox.2026.104333
PMCID: PMC13487608

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