Deficiency of the commensal Bacteroides vulgatus exacerbates skeletal muscle damage in mouse and human models of Duchenne Muscular Dystrophy

Abstract excerpt

<title>Abstract</title> <p>Gut microbiota perturbations are increasingly implicated in skeletal muscle disorders. In this study, we analyzed fecal samples from mice and humans with Duchenne muscular dystrophy (DMD), a severe X-linked myopathy, and found significant alterations in the abundance of commensal Bacteroides species compared to healthy control individuals. This prompted us to focus on <italic>Bacteroide...

Topics

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• Adipose Tissue and Metabolism
• Diet and metabolism studies
• Disease Models, Animal
• Dystrophin
• Exercise and Physiological Responses
• Fibromyalgia and Chronic Fatigue Syndrome Research
• Gut microbiota and health
• Muscle Physiology and Disorders

Identifiers and source

Literature Corpus work

e8c74d0f-94c2-59ba-b573-266ff3dd716d

DOI

10.21203/rs.3.rs-6818955/v1