Rare variant association studies: Significance, methods, and applications in chronic pain studies.

Abstract excerpt

Rare genetic variants, characterized by their low frequency in a population, have emerged as essential components in the study of complex disease genetics. The biology of rare variants underscores their significance, as they can exert profound effects on phenotypic variation and disease susceptibility. Recent advancements in sequencing technologies have yielded the availability of large-scale sequencing data such...

Topics

• Humans
• Chronic Pain
• Genetic Variation
• Exome Sequencing
• Genetic Predisposition to Disease
• Genetic Association Studies
• Genome-Wide Association Study