Article
Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.
Annals of the rheumatic diseases - 1 Mar 2013
Peters Marjolein J, Broer Linda, Willemen Hanneke L D M, Eiriksdottir Gudny, Hocking Lynne J, Holliday Kate L, Horan Michael A, Meulenbelt Ingrid, Neogi Tuhina, Popham Maria, Schmidt Carsten O, Soni Anushka, Valdes Ana M, Amin Najaf, Dennison Elaine M, Eijkelkamp Niels, Harris Tamara B, Hart Deborah J, Hofman Albert, Huygen Frank J P M, Jameson Karen A, Jones Gareth T, Launer Lenore J, Kerkhof Hanneke J M, de Kruijf Marjolein, McBeth John, Kloppenburg Margreet, Ollier William E, Oostra Ben, Payton Antony, Rivadeneira Fernando, Smith Blair H, Smith Albert V, Stolk Lisette, Teumer Alexander, Thomson Wendy, Uitterlinden André G, Wang Ke, van Wingerden Sophie H, Arden Nigel K, Cooper Cyrus, Felson David, Gudnason Vilmundur, Macfarlane Gary J, Pendleton Neil, Slagboom P Eline, Spector Tim D, Völzke Henry, Kavelaars Annemieke, van Duijn Cornelia M, Williams Frances M K, van Meurs Joyce B J
Abstract excerpt
BACKGROUND AND OBJECTIVES: Chronic widespread pain (CWP) is a common disorder affecting ∼10% of the general population and has an estimated heritability of 48-52%. In the first large-scale genome-wide association study (GWAS) meta-analysis, we aimed to identify common genetic variants associated with CWP. METHODS: We conducted a GWAS meta-analysis in 1308 female CWP cases and 5791 controls of European descent,...
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