Article

A multi-trait approach improves polygenic risk scores for chronic back pain across population-based and clinically ascertained samples

2025-08-29

Abstract excerpt

Chronic back pain (CBP) is a complex, heritable condition, and a leading cause of global disability. Previous genome-wide (GW) CBP polygenic risk scores (PRS) derived from a large-scale cohort have shown low discrimination without clinical validation. To improve PRS performance and clinical relevance, we applied Multi-Trait Analysis of GWAS (MTAG) to summary statistics from five genetically correlated traits of Eu...

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Literature Corpus work: 7011b97f-f84c-5b51-8877-d7a0e82c1df2
DOI: 10.1101/2025.08.27.25334588

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