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Article

Noncoding rare variants in PANX3 are associated with chronic back pain.

Pain - 1 Apr 2023

Belonogova Nadezhda M, Kirichenko Anatoly V, Freidin Maxim B, Williams Frances M K, Suri Pradeep, Aulchenko Yurii S, Axenovich Tatiana I, Tsepilov Yakov A

Abstract excerpt

ABSTRACT: Back pain is the leading cause of years lived with disability worldwide, yet surprisingly, little is known regarding the biology underlying this condition. The impact of genetics is known for chronic back pain: its heritability is estimated to be at least 40%. Large genome-wide association studies have shown that common variation may account for up to 35% of chronic back pain heritability; rare variants...

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PMID: 36448979
DOI: 10.1097/j.pain.0000000000002781
PMCID: PMC10014492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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