Article
Kindlin-1 and -2 have overlapping functions in epithelial cells implications for phenotype modification.
The American journal of pathology - 1 Mar 2011
He Yinghong, Esser Philipp, Heinemann Anja, Bruckner-Tuderman Leena, Has Cristina
Abstract excerpt
Kindlins are a novel family of intracellular adaptor proteins in integrin-containing focal adhesions. Kindlin-1 and -2 are expressed in the skin, but whether and how they cooperate in adult epithelial cells have remained elusive. We uncovered the overlapping roles of kindlin-1 and -2 in maintaining epithelial integrity and show that the phenotype of kindlin-1-deficient cells can be modulated by regulating...
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