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HA thermostability mutations S84F, G167N, and D168N potentiate H9N2 virus transmission in a warming environment.

Emerging microbes & infections - 1 Dec 2026

Pei Xinyi, Chen Wei, Xiao Hanyan, Ren Bin, Guo Chaoxuan, Gao Xinyu, Peng Zhoushuang, Zhang Lingkai, Sun Qingshuai, Hu Zhibin, Zhou Hongbo, Ma Shujie, Li Xuyong, Su Wen

Abstract excerpt

Avian influenza A (H9N2) viruses are widespread in poultry and occasionally infect mammals, contributing genes to other emerging strains. The factors that allow these viruses to withstand higher temperatures are not well understood. In this study, we used high-temperature selection and deep mutational scanning of a saturated H9N2 hemagglutinin (HA) mutant library. We identified three HA mutations, S84F, G167N,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42343620
DOI: 10.1080/22221751.2026.2695528
PMCID: PMC13347855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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