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Structural and functional characterization of the mouse multidrug resistance gene family.

Bulletin du cancer - 1 Jan 1990

Dhir R, Buschman E, Gros P

Abstract excerpt

The mouse multidrug resistance (mdr) gene family is composed of three closely related genes mdr1, mdr2 and mdr3. To clarify the role of these three genes in the emergence of multidrug resistance and to initiate a structure-function analysis of the corresponding proteins, we have isolated full length cDNA clones corresponding to their respective cellular RNA transcripts. Sequence analyses indicate that the three...

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PMID: 1980424

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