Structural and functional characterization of the mouse multidrug resistance gene family.

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Article

Structural and functional characterization of the mouse multidrug resistance gene family.

Bulletin du cancer - 1 Jan 1990

Dhir R, Buschman E, Gros P

Abstract excerpt

The mouse multidrug resistance (mdr) gene family is composed of three closely related genes mdr1, mdr2 and mdr3. To clarify the role of these three genes in the emergence of multidrug resistance and to initiate a structure-function analysis of the corresponding proteins, we have isolated full len...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Adenosine Triphosphate
Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Chromosome Mapping
Cricetinae
Drug Resistance
Gene Expression Regulation
Genes
Membrane Glycoproteins
Mice
Mutagenesis, Site-Directed
Phenotype
Transfection

Source

Open in PubMed

Identifiers

PMID: 1980424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1980424-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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