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Article

CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice.

American journal of respiratory cell and molecular biology - 1 Nov 2000

Mehlhop P D, van de Rijn M, Brewer J P, Kisselgof A B, Geha R S, Oettgen H C, Martin T R

Abstract excerpt

Asthma is characterized by immunoglobulin (Ig) E production, infiltration of the respiratory mucosa by eosinophils (EOSs) and mononuclear cells, and bronchial hyperresponsiveness (BHR). Interaction of CD40 on B cells and antigen presenting cells, with its ligand (CD40L) expressed transiently on activated T cells, is known to augment both T cell-driven inflammation and humoral immune responses, especially IgE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11062143
DOI: 10.1165/ajrcmb.23.5.3954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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