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Article

CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung.

Nature medicine - 1 Nov 2010

Mionnet Cyrille, Buatois Vanessa, Kanda Akira, Milcent Valerie, Fleury Sebastien, Lair David, Langelot Marie, Lacoeuille Yannick, Hessel Edith, Coffman Robert, Magnan Antoine, Dombrowicz David, Glaichenhaus Nicolas, Julia Valerie

Abstract excerpt

Allergic asthma is a T helper type 2 (T(H)2)-dominated disease of the lung. In people with asthma, a fraction of CD4(+) T cells express the CX3CL1 receptor, CX3CR1, and CX3CL1 expression is increased in airway smooth muscle, lung endothelium and epithelium upon allergen challenge. Here we found t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21037587
DOI: 10.1038/nm.2253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21037587-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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