Article

Impaired STING activation due to a variant in the E3 ubiqitin ligase AMFR in a patient with severe VZV infection and hemophagocytic lymphohistiocytosis

2022-08-05

Abstract excerpt

<title>Abstract</title> <p>Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus exclusively infecting humans, where it causes two distinct pathologies: varicella (chickenpox) upon primary infection and herpes zoster (shingles) following reactivation. In susceptible individuals, VZV can give rise to more severe clinical manifestations, including disseminated infection, pneumonitis, encephalitis, and vasc...

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Literature Corpus work: 2de8d216-638f-563b-82da-bb073512ae84
DOI: 10.21203/rs.3.rs-1804624/v1

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