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Article

Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression.

Science translational medicine - 12 Sept 2018

Mohamed Belal A, Hartmann Nico, Tirilomis Petros, Sekeres Karolina, Li Wener, Neef Stefan, Richter Claudia, Zeisberg Elisabeth M, Kattner Lars, Didié Michael, Guan Kaomei, Schmitto Jan D, Lehnart Stephan E, Luther Stefan, Voigt Niels, Seidler Tim, Sossalla Samuel, Hasenfuss Gerd, Toischer Karl

Abstract excerpt

Increased sarcoplasmic reticulum (SR) Ca2+ leak via the cardiac ryanodine receptor (RyR2) has been suggested to play a mechanistic role in the development of heart failure (HF) and cardiac arrhythmia. Mice treated with a selective RyR2 stabilizer, rycal S36, showed normalization of SR Ca2+ leak and improved survival in pressure overload (PO) and myocardial infarction (MI) models. The development of HF, measured...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Constriction, Pathologic

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Source

Identifiers

PMID: 30209242
DOI: 10.1126/scitranslmed.aan0724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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