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Article

Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia.

Circulation research - 31 Aug 2012

Shan Jian, Xie Wenjun, Betzenhauser Matthew, Reiken Steven, Chen Bi-Xing, Wronska Anetta, Marks Andrew R

Abstract excerpt

RATIONALE: Atrial fibrillation (AF) is the most common cardiac arrhythmia, however the mechanism(s) causing AF remain poorly understood and therapy is suboptimal. The ryanodine receptor (RyR2) is the major calcium (Ca2+) release channel on the sarcoplasmic reticulum (SR) required for excitation-c...

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Source

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Identifiers

PMID: 22828895
DOI: 10.1161/CIRCRESAHA.112.273342
PMCID: PMC3734386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22828895-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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