Article
Paradoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia.
Circulation - 24 Jul 2012
Neco Patricia, Torrente Angelo G, Mesirca Pietro, Zorio Esther, Liu Nian, Priori Silvia G, Napolitano Carlo, Richard Sylvain, Benitah Jean-Pierre, Mangoni Matteo E, Gómez Ana María
Abstract excerpt
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia is characterized by stress-triggered syncope and sudden death. Patients with catecholaminergic polymorphic ventricular tachycardia manifest sinoatrial node (SAN) dysfunction, the mechanisms of which remain unexplored. METHODS AND RESULTS: We investigated SAN [Ca(2+)](i) handling in mice carrying the catecholaminergic polymorphic ventricular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.