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Article

Serial Circulating Tumor DNA in Predicting and Monitoring the Effect of Neoadjuvant Chemoradiotherapy in Patients with Rectal Cancer: A Prospective Multicenter Study.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2021

Zhou Jiaolin, Wang Changxi, Lin Guole, Xiao Yi, Jia Wenzhuo, Xiao Gang, Liu Qian, Wu Bin, Wu Aiwen, Qiu Huizhong, Zhang Fuquan, Hu Ke, Xue Huadan, Shen Zhanlong, Wang Zhenjun, Han Jiagang, Niu Beizhan, Xu Yaping, Yu Zicheng, Yang Ling

Abstract excerpt

PURPOSE: We investigated the value of circulating tumor DNA (ctDNA) in predicting tumor response to neoadjuvant chemoradiotherapy (nCRT), monitoring tumor burden, and prognosing survival in patients with locally advanced rectal cancer (LARC). EXPERIMENTAL DESIGN: This prospective multicenter trial recruited 106 patients with LARC for treatment with nCRT followed by surgery. Serial ctDNAs were analyzed by...

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PMID: 33046514
DOI: 10.1158/1078-0432.CCR-20-2299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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