Article
Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease.
Human molecular genetics - 15 May 2016
Offenbacher Steven, Divaris Kimon, Barros Silvana P, Moss Kevin L, Marchesan Julie T, Morelli Thiago, Zhang Shaoping, Kim Steven, Sun Lu, Beck James D, Laudes Matthias, Munz Matthias, Schaefer Arne S, North Kari E
Abstract excerpt
Genome-wide association studies (GWAS) of chronic periodontitis (CP) defined by clinical criteria alone have had modest success to-date. Here, we refine the CP phenotype by supplementing clinical data with biological intermediates of microbial burden (levels of eight periodontal pathogens) and local inflammatory response (gingival crevicular fluid IL-1β) and derive periodontal complex traits (PCTs) via principal...
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