Innate Immunity Gene Variants Affect Periodontitis Susceptibility.

Abstract excerpt

Periodontitis is a chronic bacterial infection that destroys the epithelial attachment, forming a crevice beneath the gingival margins. The bacteria form dentally attached biofilms that enter the crevice and cause systemic inflammatory diseases (comorbidities). Susceptibility to moderate or severe (established) periodontitis is associated with smoking, diabetes, inadequate oral hygiene, and a genetic factor...

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• Biofilms
• CD14 gene
• Genetic Predisposition to Disease
• Immunity, Innate
• Interleukin-1beta